The first Chimeric Antigen Receptor T-cell therapy (CAR T) for cancer was approved by US Food and Drug Administration (FDA) on August 30, 2017. As of 2025, a total of seven CAR T-cell therapies have been FDA approved. All of which have shown strong efficacy in the fight against cancer.
Although CAR T-cell therapies have led the way in the fight against cancer, especially blood cancer, researchers believe the next great breakthrough will come from Natural Killer cell based therapies.
As STAT, a health, medicine, and life sciences publication reports “NK cells are rapid responders in the fight against cancer that can recognize and destroy tumor cells without prior training.
“Unlike most T cell therapies, which require modifying each patient’s own cells, NK cells can be sourced from healthy donors, stem cells or cord blood banks to create an off-the-shelf, scalable treatment option.
“This difference could sidestep major hurdles in cell therapy, including high costs of therapy, toxicities and manufacturing bottlenecks that leave many patients without options.”
There are now clinical evidence showing that NK cells have the capability of delivering the results of CAR T cells, but with additional benefits including:
Lower toxicity, improved accessibility and scalability, and the potential to treat a wider range of cancer types beyond blood cancer.
For this reason, among others, CytoMed Therapeutics (a Singapore-based biotech listed on the Nasdaq with ticker symbol GDTC) has developed multiple products pipeline that include NK cell-based immunotherapy.
The company’s pipeline of cellular immunotherapies is based on novel technologies to manufacture “off-the-shelf” cellular-based cancer immunotherapies from healthy doner blood.
These products include the CAR-γδ T cell technology (CTM-N2D), unmodified γδ T cell technology (CTM-GDT) and iPSC-derived γδ NKT cell technology (gdNKT).
Excitingly, the gdNKT therapy exploits the combinatorial benefits of two immune cell types; the multiple antigen recognition systems of natural killer (NK) cells, and the GVHD (graft vs host disease) resistant γδ T cells for the treatment of a broad range of solid and blood cancers.
As noted earlier, STAT says, “Unlike most T cell therapies, which require modifying each patient’s own cells, NK cells can be sourced from healthy donors, stem cells or cord blood banks to create an off-the-shelf, scalable treatment option.”
In an effort to bolster its gdNKT technology, last October CytoMed acquired the cord blood banking license and assets of LongevityBank.
See more of CytoMed’s product pipeline, HERE
Or read STAT’s coverage on NK cells, HERE
It’s been about 18 years since a four year girl diagnosed with neuroblastoma (a solid tumor cancer) received her first CAR T-cell therapy in clinical trial. Now in her 20’s, she’s been cancer-free for nearly two decades, one of the longest reported remissions following this breakthrough therapy.
However, while tens of thousands of patients have been treated to date with CAR T-cell therapies worldwide, many with great success, this particular case stands as a testament to science, and most importantly, where it is headed.
You see, the vast majority of CAR T-cell recipients are treated for hematological or blood cancers, as solid tumors like neuroblastoma have been, thus far, difficult to effectively target. Unfortunately for most of the patients in the trial cited above, the results were mixed.
Of the 19 children treated with CAR T-cell therapy (all diagnosed with neuroblastoma), 12 unfortunately died within seven years of treatment, and five were disease free after 10-15 years, with one patient (the young lady mentioned above) still in remission.
But a new clinical trial is soon taking place in India, with the ultimate objective to make cell therapy accessible to more patients.
CytoMed Therapeutics (NASDAQ: GDTC) in collaboration with SunAct Cancer Institute, has entered a Phase 1/Phase 2 clinical trial using CytoMed’s proprietary allogeneic gamma delta T cells for treating various cancers, including solid tumors.
Peter Choo, Chairman of CytoMed Therapeutics said, “CytoMed’s collaboration with SunAct is timely and complements our core focus of harnessing CytoMed’s proprietary off-the-shelf technologies to develop novel donor-derived cell-based allogeneic immunotherapies for the treatment of various cancers at affordable cost.
“We are aligned with the foresight of our partner SunAct to provide affordable no-option cancer therapeutics that could improve patients’ quality of life.”
Ultimately, should the trial prove successful, the company hopes to increase remission rates for solid tumor patients, while creating a CAR T-cell therapy that is far more affordable, wide ranging and accessible.
To read more about the CytoMed/SunAct collaboration, visit HERE
Or, to read more about the young lady who is nearing the two decade mark in remission, visit HERE
New research from SNS Insider shows the Regenerative Medicine Market is projected to be valued at $235.98 billion by 2032. Notably, the firm says the market, valued at $32.50 billion in 2023, is experiencing significant growth due to new, innovative therapies for chronic disease and advances in stem cell technology.
These new and innovative therapies look to target chronic disease, cancer, genetic disorders and degenerative conditions.
“In 2023, cell therapy held the dominant share of the regenerative medicine market, accounting for 35% of the total market share. This segment is experiencing robust growth due to its broad applicability in various therapeutic areas such as oncology, musculoskeletal disorders, and neurological diseases.
“The introduction of innovative treatments like CAR-T cell therapy has dramatically advanced the efficacy of cancer therapies, particularly in treating blood cancers such as leukemia and lymphoma,” an excerpt from the report shows.
Of the new research, Peter Choo, Chairman of CytoMed Therapeutics (NASDAQ: GDTC) said, “The prevalence of both chronic, degenerative disease and cancer is, unfortunately on the rise due to an aging world. I agree with SNS’s assessment of the 2032 market value for therapeutics targeting these conditions.
“I would add, however, CytoMed is right now working on CAR T-cell therapies that that target solid cancers. Not only blood cancers like leukemia and lymphoma as the report notes, but an entire host of solid tumors as well.
“For this reason, and of course to assist patients of cancer and degenerative diseases, CytoMed Therapeutics has not only concentrated its efforts on its advanced, off-the-shelf allogenic CAR T-cell cancer therapies, but has acquired the valued assets of cord blood bank CellSafe International.
“This acquisition gives us direct access to rare precious cord blood. Naïve cord blood offers a wide range of opportunities in the fields of regenerative medicine and aging diseases, including auto-immune diseases.
“Further, we were able to acquire CellSafe’s assets at a very reasonable cost. These resources, combined with our scientific expertise, may allow the company to introduce advanced cell technology products into the fast-growing regenerative medicine market,” he said.
For more information on CytoMed Therapeutics and its acquisition of Cord Blood Bank, CellSafe International, visit HERE
Or, to access to the SRS report on Regenerative Medicine, visit HERE