cytomed – cytomed

CytoMed's Technologies

CytoMed is translating its patent-pending technologies into gamma delta (γδ) T cell- and natural killer (NK) cell-based "off-the-shelf"
immunotherapeutics for a wide range of cancers.

CytoMed also engages in generating induced pluripotent stem cells (iPSCs) and developing them into cellular therapeutics using
our proprietary technologies for our customers.

#01

iPSC-γδ NKT Cell Technology
(gdNKT Therapy)

#02

CAR-γδ T Cell Technology
(CTM-N2D Therapy)

CytoMed Therapeutics

Incorporated in 2018, CytoMed Therapeutics is a spin-off from Singapore’s Agency for Science, Technology and Research (A*Star) focused on engineering more affordable cellular cancer therapies to identify and attack a multitude of solid & hematological cancers.

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Publications

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Beta-2 Microglobulin Knockout K562 Cell-Based Artificial Antigen Presenting Cells For Ex Vivo Exp...

Chen C,Du Z,Li Z,Tay JC,Wang S,Zha S,

Immunotherapy 2019, 11: 967- 982

Chimeric Switch Receptor: Switching for Improved Adoptive T-Cell Therapy Against Cancers

Tay JC,Wang S,Zha S,

Immunotherapy 2017, 9: 1339- 1349

Co-Expansion of Cytokine-Induced Killer Cells and Vγ9Vδ2 T Cells for CAR T-Cell Therapy

Chen C,Chi Z,Du SH,Kwang TW,Li Z,Tan WK,Wang S,Xu XH,

PLOS ONE 2016, 11: e0161820

CXCR1 Expression to Improve Anti-Cancer Efficacy of Intravenously Injected CAR-NK Cells in Mice w...

Ng YY,Tay JC,Wang S,

Molecular Therapy 2021, 16: 75- 85

Electroporation of NKG2D RNA CAR Improves Vγ9Vδ2 T Cell Responses against Human Solid Tumor Xenog...

Ang WX,Chen C,Chi Z,Li Z,Ng YY,Tan WK,Tay JC,Toh HC,Wang S,Xiao L,Zeng J,

Molecular Therapy 2020, 17: 421- 430

Antigenically Modified Human Pluripotent Stem Cells Generate Antigen-Presenting Dendritic Cells

Wang S,Wu C,Zeng J,

Scientific Reports 2015, 5: 15262

Baculoviral Vector-Mediated Transient and Stable Transgene Expression in Human Embryonic Stem Cells

Du J,Palanisamy N,Wang S,Zeng J,Zhao Y,

Stem Cells 2009, 25: 1055- 1061

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T...

Tang SY,Wang S,Zeng J,

PLOS ONE 2019, 14: e0216815

Enhancing Immunostimulatory Function of Human Embryonic Stem Cell-Derived Dendritic Cells by CD1d...

Shahbazi M,Toh HC,Wang S,Wu C,Zeng J,

The Journal of Immunology 2012, 188: 4297- 4304

Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Plu...

Tang SY,Toh LL,Wang S,Zeng J,

Stem Cell Reports 2017, 9: 1796- 1812