iPSC-γδ NKT Cell Technology (gdNKT Therapy)

Induced pluripotent stem cells (iPSCs) are capable of self-renewing and differentiating into any cell types of the body. iPSCs represent an unlimited starting cell source to generate therapeutic cells of various functions. For cancer treatment, immune cells such as γδ T cells and NK cells are invaluable therapeutic cells since they naturally express an array of built-in receptors to recognize cancers.

By combining iPSC technology and directed differentiation, we are able to generate a novel type of synthetic immune cells, γδ NKT cells that express cancer recognition receptors of both γδ T cells and NK cells from iPSCs to recognize a wide range of cancers without genetic modification.

Why we start with iPSCs?

iPSCs provide an unlimited starting cell source to generate unlimited therapeutic cells

of various functions - our firsthand experience.

Genetic Modification

Differentiation

Genetic Modification

Differentiation

Differentiation

iPSCs/hESCs

Cardiomyocytes

Cardiomyocytes

Neurons

Neurons

Neurons

Neurons

D-Cells

Dendritic Cells

D-Cells

Dendritic Cells

Why we generate γδ NKT cells?

To integrate more cancer recognition capabilities into one potent therapeutic product.

iPSC_grouped_image_two_image

How we generate γδ NKT cells from iPSCs?
From γδ T cell to stem cells and back with more - our synthetic strategy of γδ NKT cells.

iPSC_grouped_image_three
science_nkt_one

γδ T-iPSCs

Proprietary differentiation protocol

science_nkt_one

γδ NKT cells

Unique product features of γδ NKT cells

Cell-Report
  • Proven-safe natural cancer recognition system
  • Targeting stress-induced cancer antigens
  • Pattern recognition via targeting multiple antigens
  • Unlimited, high-purity and potent
  • Bona fide “off-the-shelf” product
  • Applicable to a broad spectrum of cancers
  • Applicable to a large pool of patients

Function of γδ NKT cells? γδ NKT cells are potent
cancer killers

γδ NKT cells in action
− γδ NKT cells killing colon cancer cells.

science_nkt_one

Seek, see and destroy
− unravelling the action of γδ NKT cells frame by frame.