For many blood cancer patients, chimeric antigen receptor (CAR) T-cell therapies have been a life saver. This exciting and promising technology has shown to produce powerful and prolonged immune responses, often destroying the cancer cells they target.
However, the caveats of current FDA approved CAR T-cell therapies are 1) time consuming due to their “customized” nature that can take several weeks to manufacture, 2) engineered directly from the affected patients’ own cells (autologous) and 3) mostly applicable for blood cancer treatment, with a few upcoming FDA approved CAR T-cell products specific for solid cancers such as Tecelra® (soft tissue cancer) and Amtagvi® (melanoma).
Enter the allogeneic and “off the shelf” immune cell-based therapies. These therapies are based on immune cells such as T cells and natural killer (NK) cells that are manufactured from healthy donor cells, stored, and used on demand, resulting in a significant reduction in the “wait” time for cancer treatment from weeks to days.
Now, several companies are in the process of creating NK cell-based cancer therapies and, according to the American Association of Cancer Research, they’re getting close to a solution.
Senti-Biosciences, for example, recently showed several patients experiencing complete remission of acute myeloid leukemia (AML) after being treated with their CAR-NK cell-based cancer therapy platform. But Senti is not the only company diligently working on a solution.
Peter Choo, Chairman of Singapore-based CytoMed Therapeutics (NASDAQ: GDTC) said, “It is very encouraging to see these early data from Senti. It is our belief that NK cell-based cancer therapies will be the next great breakthrough in cancer therapy.
“Our company, CytoMed, is developing an iPSC-γδ NK T-cell therapy product which we hope to reveal some data on, perhaps sometime later this year, or early next. This product is engineered as an allogeneic solution, which we believe ultimately could target a wide range of cancers and could do so at a lower cost than current, more narrowly targeted and time-consuming, CAR T-cell solutions.
“We encourage the scientific community to review our technology and see why we start with iPSCs at https://w2.cytomed.sg/ipsc-gamma-delta-nkt-cell/,” he concluded.
To read more about CytoMed Therapeutics, visit HERE
Or, for a quick review of the Senti data shown in The American Journal of Managed Care®, visit HERE
According to data compiled by the South China Morning Post, small Asian biotechs are developing cancer therapies that may cost a fraction of those of their Western counterparts, with development occurring a rapid pace.
“A decade ago, treating cancer with personalized [therapies] seemed like a $1 million gamble per patient, a therapy reserved for the ultra-rich.
But [Asian] start-ups are aiming to change that – by designing cancer therapy for a fraction of the cost and also taking on Western pharmaceutical giants in the process,” the publication said.
It is estimated that the current cost of chimeric antigen receptor T-cell therapy (CAR T-cell), which is among the most responsive and promising cancer treatments, can run well over $400,000 per patient in the United States.
Due to this high cost, patient access is very limited to those who can afford it, or whose insurance can fully cover it.
However, one Singapore-based company, CytoMed Therapeutics (NASDAQ: GDTC) believes its CAR T-cell therapies, once brought to market, can reduce patient care costs drastically.
Peter Choo, Chairman of CytoMed Therapeutics said, “In Asia, we have a unique situation where the costs of research, development and production of biopharmaceuticals are generally far less expensive than we see in the West.
“There are a number of reasons why, but we clearly have a very large advantage in these areas. Because of this I believe companies like ours, and others in Asia, will eventually produce cancer therapies that cost perhaps 99% less than those developed and produced outside of Asia.
“Of course, doing so would not only make cancer treatments far less expensive but would bring this life-saving technology to a much larger pool of patients,” he said.
The majority of CAR T-cell therapies on the market are based on manufacturing and engineering cells from the cancer patient’s blood that only target hematological malignancies, or blood cancers. However, CytoMed’s pipeline of products look to advance “off-the-shelf” based allogeneic immunotherapies by manufacturing and engineering cells from healthy blood doners to treat a broad range of cancers, including both blood cancer and solid tumors.
Furthermore, the company looks to manufacture broad-range and cost-effective immunotherapeutic products in an area of the world where the associated costs of research and development, and manufacturing are a fraction of those in the West.
To read more about CytoMed’s CAR T-cell therapies, and its product pipeline, visit HERE
Or, to read more about the data compiled in the South China Morning Post, visit HERE
The market for cell banking is expanding rapidly, with a global estimate market of $5 billion USD in 2022. However, according to new research from DataM Intelligence, the market is expanding at a 15.68% compound annual growth rate and is expected to hit an estimate valuation of $15.9 billion USD by 2031.
According to its report, “The Stem Cell Banking market focuses on the collection, processing, and storage of stem cells from sources like umbilical cord blood, bone marrow, and adipose tissue for future medical use. Rising awareness of regenerative medicine, advancements in stem cell therapies, and increasing prevalence of chronic diseases are driving market growth globally.”
What makes this market so exciting for companies like CytoMed Therapeutics (NASDAQ: GDTC), outside its remarkable CAGR, is the utility of umbilical cord blood.
As noted in a review article by The National Library of Medicine, “While cord blood is primarily utilized in allogeneic hematopoietic cell transplantation, the development of novel cell therapy products from cord blood is a growing and developing field.
“Compared to adult blood, cord blood is characterized by a higher percentage of hematopoietic stem cells and progenitor cells, less mature immune cells that retain a high capacity of proliferation, and stronger immune tolerance that requires less stringent HLA-matching when used in the allogenic setting.
“… cord blood lends itself as a readily available and safe starting material for the development of off-the-shelf cell therapies. Moreover, non-hematologic cells… also have potential in regenerative medicine and inflammatory and autoimmune conditions.”
For these reasons, among others, CytoMed Therapeutics, through its subsidiary IPSC Depository, recently acquired certain assets of Malaysian cord blood bank, Cellsafe International.
Evelyn Tan, IPSC Depository CEO said, “This acquisition seeks to unlock the therapeutic potential of umbilical cord blood and adds a new strategic dimension targeting longevity and wellness.
“While CytoMed, our publicly listed holding company, will continue to focus on cancer therapeutics, our new subsidiary, LongevityBank will focus exclusively on the regenerative medicine market, with its ultimate goal to be potentially spun off in the future.”
Research from SNS Insider shows the Regenerative Medicine Market is projected to be valued at $235.98 billion by 2032. By obtaining and growing a foothold in this particular segment, CytoMed Therapeutics, through its subsidiaries, looks to grow not only its market shares, but also to diversify its overall product offerings in the health and wellness space.
Read the DataM Intelligence report on the stem cell banking market, HERE
Or see the latest press releases from CytoMed Therapeutics (NASDAQ: GDTC), HERE
On August 30, 2017, the US Food and Drug Administration approved the very first Chimeric Antigen Receptor T-cell therapy (CAR T-cell), tisagenlecleucel (KymriahTM), for treatment of pediatric and young adult Acute Lymphoblastic Leukemia. Eight years subsequently, we have witnessed tremendous advancements of immunotherapy in basic research and their breakthrough into clinical trials.
This is evident from the observation that seven CAR T-cell based cancer therapies were approved in the US in 2024 alone. Furthermore, there are over 1,000 clinical trials ongoing worldwide, in various stages, exploring this exciting technology for the treatment of diverse tumor types.
Mary McGann, PharmD, BCOP – a clinical pharmacy specialist in bone marrow transplant and cellular therapy – told Pharmacy Practice News, it’s “Definitely an exciting time. I feel like every year we almost double the number of CAR-T patients that we have.”
With the FDA having approved an additional six CAR T-cell treatments for use in qualified patients to date, the global market for CAR T-cell therapies is expected to reach at least $27 billion by 2033.
Amongst the companies participating in clinical trials right now, Cytomed Therapeutics (NASDAQ: GDTC) is exploring the use of its products as an “off-the-shelf” allogeneic cellular immunotherapy to be used for a broad spectrum of cancers.
Unlike most CAR T-cell therapies, CytoMed’s products aim to use healthy donor cells, rather than cells from compromised patients, to engineer the therapy by developing a single allogeneic product for the treatment of a wide array of cancers.
The company has an ongoing clinical trial currently in Singapore, with and an upcoming trial in India.
Cytomed Therapeutics’ Chairman, Peter Choo, said of the global increase in clinical trials and FDA approvals, “The science behind CAR T-cell therapies has shown to be a real-life saver. It is exciting to see the US FDA finally taking notice of its promise.
“While we are currently involved in two separate trials, we do believe this year, 2025, could very well prove to be the year where we, and the industry as a whole, are proven to not only be viable, but essential in the global fight against cancer.
“Further, our products, as a differentiator, look to treat a multitude of tumors, both solid and liquid, via commercial production, and to do so at a much lower cost than current therapies.
“By achieving this, we believe we could open up treatment for far more patients, with hopes of saving far more lives.”
With the large number of CAR T-cell therapies currently in clinical trials, the outlook for 2025 is very bright. However, the average cost per patient for CAR T-cell therapy in the United States often exceeds $400,000.
The key to real success, outside of patient remission, will be, as Mr. Choo believes, bringing the cost of CAR T-cell therapies down significantly, which is CytoMed’s core approach with its technology.
Read more about CytoMed Therapeutics’ pipeline, HERE